3-氰基-3-(4-羟基哌啶-1-基)吡咯烷-1-羧酸乙酯合成路线 （共 2 条）
反应条件
1: 4-hydroxy-piperidine; ethyl 3-oxo-1-pyrrolidine-carboxylate With titanium(IV) isopropylate in 1,2-dichloro-ethane T=20°C; 2: diethyl aluminium cyanide in 1,2-dichloro-ethane T=20°C; 24 h;
参考文献
ASTRAZENECA AB
Patent: US2009/221567 A1, 2009 ;
Location in patent: Page/Page column 59 ;
US 20090221567 A1
反应条件
1: in tetrahydrofuran; toluene T=0 - 20°C; 12 h; 2: With water; ammonium chloride in tetrahydrofuran; toluene T=0°C;
参考文献
ASTRAZENECA AB
Patent: US2009/221567 A1, 2009 ;
Location in patent: Page/Page column 59 ;
US 20090221567 A1
