4-(二氟甲氧基)-3-碘苯甲酸甲酯合成路线 （共 6 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=0 - 20°C; 3 h; Inert atmosphere;
参考文献
WYETH LLC; LI, David, Zenan; O'NEIL, Steven, Victor; SPRINGER, Dane, Mark; ZEGARELLI, Benjamin, Miller
Patent: WO2010/124047 A1, 2010 ;
Location in patent: Page/Page column 58-59 ;
WO 2010/124047 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=93 - 98°C; 4.25 h; Large scale reaction;
参考文献
Sperry, Jeffrey B.; Sutherland, Karen
Organic Process Research and Development, 2011 , vol. 15, # 3 p. 721 - 725
反应条件
potassium carbonate in N,N-dimethyl-formamide T=95°C;
参考文献
Sperry, Jeffrey B.; Sutherland, Karen
Organic Process Research and Development, 2011 , vol. 15, # 3 p. 721 - 725
反应条件
sodium carbonate in N,N-dimethyl-formamide T=95°C;
参考文献
Sperry, Jeffrey B.; Sutherland, Karen
Organic Process Research and Development, 2011 , vol. 15, # 3 p. 721 - 725
反应条件
1: methanol; 4-hydroxy-3-iodo-benzoic acid With thionyl chloride 2: 1-chloro-1,1-difluoro-methane With potassium carbonate in N,N-dimethyl-formamide
参考文献
Ni, Feng; Li, Jianqi
Synthesis (Germany), 2012 , vol. 44, # 23 art. no. SS-2012-H0689-OP, p. 3598 - 3602
反应条件
potassium hydroxide in water
参考文献
Ni, Feng; Li, Jianqi
Synthesis (Germany), 2012 , vol. 44, # 23 art. no. SS-2012-H0689-OP, p. 3598 - 3602
