4-(二异丙基氨基甲酰)-2-乙氧基吡啶-3-基硼酸合成路线 （共 2 条）
反应条件
1: 2-ethoxy-N,N-diisopropylisonicotinamide With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran; cyclohexane
T=-78°C; 0.333333 h;
2: boric acid trimethyl ester in tetrahydrofuran; cyclohexane
T=-78°C; 0.5 h;
3: With hydrogenchloride; water; ammonium chloride in tetrahydrofuran; cyclohexane
T=0 - 20°C; 1 h;
参考文献
MERCK and CO., INC.
Patent: WO2009/35575 A1, 2009 ;
Location in patent: Page/Page column 42 ;
WO 2009/035575 A1
反应条件
1: oxalyl dichloride / dichloromethane
2: triethylamine / dichloromethane
3: sec.-butyllithium / tetrahydrofuran / -78 °C
View Scheme
参考文献
Siu, Tony; Kumarasinghe, Sathyajith E.; Altman, Michael D.; Katcher, Matthew; Northrup, Alan; White, Catherine; Rosenstein, Craig; Mathur, Anjili; Xu, Lin; Chan, Grace; Bachman, Eric; Bouthillette, Melaney; Dinsmore, Christopher J.; Marshall, C. Gary; Young, Jonathan R.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1466 - 1471
