3,5-二甲氧基苯甲酸合成路线 （共 127 条）
反应条件
1.1: LiAlH4 / tetrahydrofuran / 3 h / 20 °C 1.2: 97 percent / Na/K tartrate / tetrahydrofuran / 1 h / 20 °C 2.1: 86 percent / PBr3 / CH2Cl2 / 1 h / 20 °C 3.1: 83 percent / dimethylformamide / 1 h 4.1: 90 percent / conc. HCl / 2.5 h / Heating View Scheme
参考文献
Almeida, Wanda P.; Correia, Carlos Roque D.
Tetrahedron Letters, 1994 , vol. 35, # 9 p. 1367 - 1370
反应条件
1: K2CO3 / acetone 2: LiAlH4 / diethyl ether 3: SOCl2 / diethyl ether 4: ethanol 5: HI, AcOH View Scheme
参考文献
Eiden; Meins
Archiv der Pharmazie, 1972 , vol. 305, # 2 p. 124 - 134
反应条件
1: K2CO3 / acetone 2: LiAlH4 / diethyl ether 3: SOCl2 / diethyl ether 4: ethanol 5: HI, AcOH 6: HCl View Scheme
参考文献
Eiden; Meins
Archiv der Pharmazie, 1972 , vol. 305, # 2 p. 124 - 134
反应条件
4: fluoroboric acid, sodium nitrite / H2O View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1658 - 1666
反应条件
sulfuric acid in benzene 2 h; Heating;
参考文献
Helvetica Chimica Acta, , vol. 63, # 6 p. 1425 - 1433
反应条件
sulfuric acid in chloroform
参考文献
, vol. No. 12, p. 2189 - 2215
反应条件
thionyl chloride in N,N-dimethyl-formamide 18 h; Heating;
参考文献
Dol, Georg C.; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.
European Journal of Organic Chemistry, 1998 , # 2 p. 359 - 364
反应条件
1: 99 percent / thionyl chloride / dimethylformamide / 18 h / Heating 2: 60 percent / AIBN, CBrCl3, 2-mercaptopyridine N-oxide sodium salt / 0.25 h / Heating View Scheme
参考文献
Dol, Georg C.; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.
European Journal of Organic Chemistry, 1998 , # 2 p. 359 - 364
参考文献
Shi, Feng; Shen, Jing Kang; Chen, Danqi; Fog, Karina; Thirstrup, Kenneth; Hentzer, Morten; Karlsson, Jens-Jakob; Menon, Veena; Jones, Kenneth A.; Smith, Kelli E.; Smith, Garrick
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 4 p. 303 - 306
反应条件
sulfuric acid; acetic acid T=85 - 90°C; 6 h; Neat (no solvent)Large scale reaction;
参考文献
Rekha; Ramani, Modukuri V.; Ratnamala; Rupakalpana, Vempati; Subbaraju, Gottumukkala V.; Satyanarayana, Chava; Rao, C. Someswara
Organic Process Research and Development, 2009 , vol. 13, # 4 p. 769 - 773
