7-氟苯并二氢吡喃-4-酮合成路线 （共 7 条）
反应条件
1: With thionyl chloride in toluene 1.5 h; Heating / reflux; 2: With trifluorormethanesulfonic acid in chloroform T=-65 - 20°C; 2 h; 3: With sodium hydroxide in chloroform; water
参考文献
US2005/38032 A1, ;
Page/Page column 30 ;
US 20050038032 A1
反应条件
1: With thionyl chloride in toluene 17 h; Heating / reflux; 2: With trifluorormethanesulfonic acid in chloroform T=-65 - 20°C;
参考文献
WO2008/151927 A2, ;
Page/Page column 62 ;
反应条件
sodium hydroxide; PPA in water
参考文献
US6316437 B1, ;
US 6316437 B1
反应条件
aluminium chloride in dichloromethane
反应条件
1: With oxalyl dichloride T=0°C; Friedel-Crafts Acylation; 2: With AlCl3, aluminium chloride in dichloromethane T=20°C; Friedel-Crafts Acylation;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 310 - 317
反应条件
1.1: sodium hydroxide / water / |Reflux 2.1: oxalyl dichloride / 0 °C 2.2: 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 310 - 317
反应条件
1.1: [bis(acetoxy)iodo]benzene; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical / water; acetonitrile / 20 °C 2.1: oxalyl dichloride / 0 °C 2.2: 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 310 - 317
