2,6-二氯-3-甲酰胺-5-氟吡啶合成路线 （共 14 条）
反应条件
1: zinc; acetic acid / methanol / 24 h / Reflux 2: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C 3: hydrazine hydrate / ethylene glycol / 4 h / Reflux View Scheme
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; Stasch, Johannes-Peter; Becker, Eva-Maria; Trübel, Hubert; Himmel, Herbert
Patent: US2013/158028 A1, 2013 ;
反应条件
lead(IV) acetate; hydrogenchloride 1.) t-BuOH, 100 deg C, 3 h, 2.) Et2O, 0 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Sraga; Guerry; Kompis
Helvetica Chimica Acta, 1994 , vol. 77, # 4 p. 1057 - 1064
反应条件
acetic acid; zinc in methanol
24 h; Reflux;
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; Follmann, Markus; Stasch, Johannes-Peter; Redlich, Gorden; Ackerstaff, Jens; Griebenow, Nils; Knorr, Andreas; Wunder, Frank; Li, Volkhart Min-Jian
Patent: US2013/172372 A1, 2013 ;
Location in patent: Paragraph 0242; 0243; 0244; 0245 ;
反应条件
acetic acid in methanol; dichloromethane
参考文献
BAYER INTELLECTUAL PROPERTY GMBH; Follmann, Markus; Itasch, Johannes-Peter; Redlich, Gorden; Griebenow, Nils; Wunder, Frank; Li, Volkhart Min-Jian; Lang, Dieter
Patent: US2014/100229 A1, 2014 ;
Location in patent: Page/Page column ;
