Grubb's 2nd generation catalyst in toluene T=65°C;

1: 2-((2R,6S,E)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl)acetic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane 0.5 h; Cooling with ice; 2: 4-chloro-benzylamine With 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 16 h;

Grubb's 2nd generation catalyst in toluene T=65°C;