L-酪氨酰-D-蛋氨酰甘氨酰-L-苯丙氨酰-N-beta-D-吡喃葡萄糖基-L-脯氨酰胺合成路线 （共 4 条）
反应条件
1: 49 percent / NaN3 / dimethylformamide / 2 h / 85 - 90 °C
2: 97 percent / H2 / PtO2 / ethyl acetate / 1 h
3: 1-hydroxybenzotriazol, 2-mercaptoethanol, dicyclohexylcarbodiimid / tetrahydrofuran / 1) -20 deg C, 1 h, 2) RT, 24 h
4: trifluoroacetic acid / CH2Cl2 / 1 h / Ambient temperature
5: NH3, trifluoroacetic acid / methanol; CH2Cl2 / 3 h / Ambient temperature; pH 10-11
View Scheme
参考文献
Vansteenkiste, Stefan; Schacht, Etienne; Haro, Isabel; Reig, Francesca; Parente, Antonio; Garcia-Anton, Jose Maria
Bulletin des Societes Chimiques Belges, 1991 , vol. 100, # 10 p. 759 - 766
反应条件
1: 97 percent / H2 / PtO2 / ethyl acetate / 1 h
2: 1-hydroxybenzotriazol, 2-mercaptoethanol, dicyclohexylcarbodiimid / tetrahydrofuran / 1) -20 deg C, 1 h, 2) RT, 24 h
3: trifluoroacetic acid / CH2Cl2 / 1 h / Ambient temperature
4: NH3, trifluoroacetic acid / methanol; CH2Cl2 / 3 h / Ambient temperature; pH 10-11
View Scheme
参考文献
Vansteenkiste, Stefan; Schacht, Etienne; Haro, Isabel; Reig, Francesca; Parente, Antonio; Garcia-Anton, Jose Maria
Bulletin des Societes Chimiques Belges, 1991 , vol. 100, # 10 p. 759 - 766
反应条件
ammonia; trifluoroacetic acid in methanol; dichloromethane
3 h; Ambient temperaturepH 10-11; Yield given;
参考文献
Vansteenkiste, Stefan; Schacht, Etienne; Haro, Isabel; Reig, Francesca; Parente, Antonio; Garcia-Anton, Jose Maria
Bulletin des Societes Chimiques Belges, 1991 , vol. 100, # 10 p. 759 - 766
反应条件
1: 1-hydroxybenzotriazol, 2-mercaptoethanol, dicyclohexylcarbodiimid / tetrahydrofuran / 1) -20 deg C, 1 h, 2) RT, 24 h
2: trifluoroacetic acid / CH2Cl2 / 1 h / Ambient temperature
3: NH3, trifluoroacetic acid / methanol; CH2Cl2 / 3 h / Ambient temperature; pH 10-11
View Scheme
参考文献
Vansteenkiste, Stefan; Schacht, Etienne; Haro, Isabel; Reig, Francesca; Parente, Antonio; Garcia-Anton, Jose Maria
Bulletin des Societes Chimiques Belges, 1991 , vol. 100, # 10 p. 759 - 766
