potassium carbonate in N,N-dimethyl-formamide T=0°C; 2 h; Inert atmosphere;

1: hydrogenchloride / ethanol; water / Inert atmosphere 2: triethylamine; magnesium chloride / acetonitrile / 0.5 h / Inert atmosphere; Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere View Scheme

1: Inert atmosphere 2: n-butyllithium / Inert atmosphere 3: hydrogenchloride / ethanol; water / Inert atmosphere 4: triethylamine; magnesium chloride / acetonitrile / 0.5 h / Inert atmosphere; Reflux 5: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere View Scheme

1: n-butyllithium / Inert atmosphere 2: hydrogenchloride / ethanol; water / Inert atmosphere 3: triethylamine; magnesium chloride / acetonitrile / 0.5 h / Inert atmosphere; Reflux 4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere View Scheme

titanium tetrachloride; sodium hydride 1.) CH2Cl2, 2.) DMF; Yield given. Multistep reaction;