1,7-二氧杂螺[5.5]十一碳-4-烯合成路线 （共 20 条）
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate T=20°C; P=760 Torr; 6 h;
参考文献
Conway, Jeremy C.; Quayle, Peter; Regan, Andrew C.; Urch, Christopher J.
Heterocycles, 2006 , vol. 67, # 1 p. 85 - 88
反应条件
Hg(OTf)2 in acetonitrile
T=20°C; 0.0833333 h; Inert atmosphere;
参考文献
Ravindar, Kontham; Sridhar Reddy, Maddi; Deslongchamps, Pierre
Organic Letters, 2011 , vol. 13, # 12 p. 3178 - 3181
反应条件
ClAu(di(tert-butyl)(1,1′-biphenyl-2-yl)-phosphine); silver trifluoromethanesulfonate in tetrahydrofuran
T=0°C; 0.25 h; Inert atmosphereMolecular sieve;
参考文献
Aponick, Aaron; Li, Chuan-Ying; Palmes, Jean A.
Organic Letters, 2009 , vol. 11, # 1 p. 121 - 124
反应条件
camphor-10-sulfonic acid in dichloromethane
T=20°C; 1 h;
参考文献
Conway, Jeremy C.; Quayle, Peter; Regan, Andrew C.; Urch, Christopher J.
Heterocycles, 2006 , vol. 67, # 1 p. 85 - 88
反应条件
hydrogen; pyridinium p-toluenesulfonate; Lindlar's catalyst
1) hexane, EtOAc, 2) CH2Cl2, rt, 0.5 h; Multistep reaction;
参考文献
Brimble, Margaret A.; Edmonds, Michael K.; Williams, Geoffrey M.
Tetrahedron Letters, 1990 , vol. 31, # 51 p. 7509 - 7512
反应条件
pyridinium p-toluenesulfonate in methanol; dichloromethane
T=20°C; 12 h;
参考文献
Whitby Richard; Kocienski, Philip
Journal of the Chemical Society, Chemical Communications, 1987 , # 12 p. 906 - 907
反应条件
potassium tert-butylate in dimethyl sulfoxide
T=110°C; 20.5 h;
参考文献
Lawson, Elvie N.; Kitching, William; Kennard, Colin H. L.; Byriel, Karl A.
Journal of Organic Chemistry, 1993 , vol. 58, # 9 p. 2501 - 2508
反应条件
1: 1.) n-butyllithium / 1.) THF, 0.75 h, -78 deg C; 2.) THF, 0.75 h, -78 deg C
2: potassium carbonate, H2 / Lindlar catalyst / hexane; ethyl acetate / 16 h
3: pyridinium p-toluenesulphonate / CH2Cl2 / 1 h
View Scheme
参考文献
Brimble; Edmonds; Williams
Tetrahedron, 1992 , vol. 48, # 31 p. 6455 - 6466
反应条件
1: 86 percent / Amberlite resin (IR-118) / methanol / 24 h
2: 98 percent / H2, quinoline, sodium hydrogen carbonate / Pd/BaSO4 / methanol
3: 68 percent / camphorsulphonic acid / CH2Cl2 / 0.17 h
View Scheme
参考文献
Baker, Raymond; Herbert, Richard H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1123 - 1128
反应条件
1: Pd2(PPh3)2Cl2; copper(l) iodide / tetrahydrofuran; diethylamine / 24 h / 20 °C / |Inert atmosphere
2: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C
3: silver trifluoromethanesulfonate; PPh3 gold(I) chloro complex / chloroform-d1
View Scheme
参考文献
Zhdanko, Alexander; Maier, Martin E.
European Journal of Organic Chemistry, 2014 , vol. 2014, # 16 p. 3411 - 3422
