3’-甲基-2,2’:5’,2’’-三联噻吩合成路线 （共 5 条）
反应条件
1: 2,5-dibromo-3-methylthiophene With tris-(dibenzylideneacetone)dipalladium(0); [(t-Bu)3PH]BF4 in tetrahydrofuran 0.25 h; 2: dihydroxy-thien-2-ylborane With potassium phosphate in tetrahydrofuran; water 3 h; Heating / reflux;
参考文献
MERCK PATENT GMBH
Patent: WO2005/80369 A2, 2005 ;
Location in patent: Page/Page column 38-39 ;
反应条件
[1,3-bis(diphenylphosphino) propane] dichloronickel(II) in diethyl ether 16 h; Heating;
参考文献
Pham, Chiem Van; Burkhardt, A.; Shabana, R.; Cunningham, David D.; Mark, Harry B.; Zimmer, Hans
Phosphorus, Sulfur and Silicon and the Related Elements, 1989 , vol. 46, p. 153 - 168
反应条件
1: thien-2-yl bromide With magnesium in diethyl ether Grignard reaction; homocoupling; 2: 2,5-dibromo-3-methylthiophene With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in diethyl ether Substitution; 3 h;
参考文献
Chaloner, Penny A.; Gunatunga, Sumudu R.; Hitchcock, Peter B.
Journal of the Chemical Society. Perkin Transactions 2, 1997 , # 8 p. 1597 - 1604
反应条件
1: thiophene With n-butyllithium in tetrahydrofuran T=-40°C; 0.666667 h; 2: With zinc(II) chloride in tetrahydrofuran T=-40 - 20°C; 3: 2,5-dibromo-3-methylthiophene With Ni(dppp)Cl2 in tetrahydrofuran T=20°C; 12 h;
参考文献
Sheina, Elena E.; Liu, Jinsong; Lovu, Mihaela Corina; Laird, Darin W.; McCullough, Richard D.
Macromolecules, 2004 , vol. 37, # 10 p. 3526 - 3528
反应条件
1: Br2 / CHCl3 / Heating 2: Ni<Ph2P(CH2)3PPh2>PCl2 / diethyl ether / Ambient temperature View Scheme
参考文献
Roncali, Jean; Giffard, Michel; Frere, Pierre; Jubault, Michel; Gorgues, Alain
Journal of the Chemical Society, Chemical Communications, 1993 , # 8 p. 689 - 691
