7-溴-咪唑并[1,2-a]吡啶-3-羧酸乙酯合成路线 （共 3 条）
反应条件
1: in ethanol; benzene T=60°C; 5 h; Inert atmosphere; 2: With sodium hydrogencarbonate in ethyl acetate
参考文献
IRM LLC; TULLY, David C.; RUCKER, Paul Vincent; ALPER, Phillip B.; MUTNICK, Daniel; CHIANELLI, Donatella
Patent: WO2012/87519 A1, 2012 ;
Location in patent: Page/Page column 112 ;
WO 2012/087519 A1
反应条件
1: With sulfuric acid in ethanol T=90°C; 3 h; 2: With triethylamine in ethanol T=20 - 90°C; 18 h;
参考文献
NOVARTIS AG; IRM LLC; BRUCE, Ian; CHAMOIN, Sylvie; COLLINGWOOD, Stephen Paul; FURET, Pascal; FURMINGER, Vikki; LEWIS, Sarah; LOREN, Jon Christopher; MOLTENI, Valentina; SAUNDERS, Alex Michael; SHAW, Duncan; SVIRIDENKO, Lilya; THOMSON, Christopher; YEH, Vince; JANUS, Diana; WEST, Ryan
Patent: WO2013/30802 A1, 2013 ;
Location in patent: Page/Page column 121; 122 ;
反应条件
1: With lithium hydroxide hydrate; water in tetrahydrofuran; ethanol T=20°C; 16 h; 2: With sulfuric acid in water pH=3; Cooling with ice-water;
参考文献
WO2011/79076 A1, ;
Page/Page column 67 ;
