4,4-二甲基-2-戊炔-1-胺合成路线 （共 3 条）
反应条件
n-butyllithium 1.) hexane, THF, -78 deg C, 1 h, 2.) hexane, THF, RT, 20 h; Yield given. Multistep reaction;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2009/77334 A1, 2009 ;
Location in patent: Page/Page column 96-97 ;
WO 2009/077334 A1
反应条件
1: 3,3-dimethylbut-1-yne With indium tribromide; triethylamine in diethyl ether T=20°C; 1 h; 2: N,N-bis(trimethylsilyl)methoxymethylamine in diethyl ether 5 h;
参考文献
Sakai, Norio; Kanada, Reiko; Hirasawa, Maki; Konakahara, Takeo
Tetrahedron, 2005 , vol. 61, # 39 p. 9298 - 9304
反应条件
1: dimethylformamide 2: 62 percent / hydrazine hydrate / ethanol View Scheme
参考文献
MacInnes, Iain; Walton, John C.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987 , p. 1077 - 1082
