4,4,4-三氟-2-丁炔-1-醇合成路线 （共 2 条）
反应条件
1: 3,3,3-trifluoro-1-propyne With n-butyllithium in diethyl ether; pentane T=-78°C; 0.0666667 h; Inert atmosphere; 2: formaldehyd in diethyl ether; pentane T=-78 - 0°C; 3: With water; ammonium chloride in diethyl ether; pentane T=0°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; CHERNEY, Robert J.; ZHANG, Yanlei
Patent: WO2011/133734 A1, 2011 ;
Location in patent: Page/Page column 56 ;
WO 2011/133734 A1
反应条件
1: 2-Bromo-3,3,3-trifluoro-propene With n-butyllithium; diisopropylamine in diethyl ether T=-78°C; 0.166667 h; 2: formaldehyd in diethyl ether T=-78 - 20°C; 3: With hydrogenchloride in diethyl ether; water
参考文献
BRISTOL-MYERS SQUIBB COMPANY; DHAR, T.G. Murali; XIAO, Hai-Yun; WATTERSON, Scott Hunter; KO, Soo S.; DYCKMAN, Alaric J.; LANGEVINE, Charles M.; DAS, Jagabandhu; CHERNEY, Robert J.
Patent: WO2011/59784 A1, 2011 ;
Location in patent: Page/Page column 79-80 ;
WO 2011/059784 A1
