(1S,4S)-2-BOC-2,5-二氮双环[2.2.1]庚烷合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Rosen, Terry; Lico, Isabella M.; Chu, Daniel T. W.
Journal of Organic Chemistry, 1988 , vol. 53, # 7 p. 1580 - 1582
反应条件
10 palladium on carbon; hydrogen
参考文献
Huang, Xiaoguang; Chen, Dongliang; Wu, Ning; Zhang, Aiqin; Jia, Zhenhua; Li, Xingshu
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4130 - 4133
反应条件
1.1: triethylamine / dichloromethane / 17 h / 0 °C 2.1: lithium borohydride / tetrahydrofuran / 26 h / 0 - 20 °C 3.1: pyridine / dichloromethane / 18 h / 40 °C 4.1: trimethylsilylazide; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 70 °C 5.1: triethylamine / dichloromethane / 0.5 h / 0 °C 6.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C 6.2: 18 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 39 p. 5345 - 5347
反应条件
1.1: thionyl chloride; hydrogenchloride / water / 18 h / 20 °C / |Reflux 2.1: triethylamine / dichloromethane / 17 h / 0 °C 3.1: lithium borohydride / tetrahydrofuran / 26 h / 0 - 20 °C 4.1: pyridine / dichloromethane / 18 h / 40 °C 5.1: trimethylsilylazide; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 70 °C 6.1: triethylamine / dichloromethane / 0.5 h / 0 °C 7.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C 7.2: 18 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 39 p. 5345 - 5347
反应条件
1.1: lithium borohydride / tetrahydrofuran / 26 h / 0 - 20 °C 2.1: pyridine / dichloromethane / 18 h / 40 °C 3.1: trimethylsilylazide; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 70 °C 4.1: triethylamine / dichloromethane / 0.5 h / 0 °C 5.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C 5.2: 18 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 39 p. 5345 - 5347
反应条件
1.1: pyridine / dichloromethane / 18 h / 40 °C 2.1: trimethylsilylazide; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 70 °C 3.1: triethylamine / dichloromethane / 0.5 h / 0 °C 4.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C 4.2: 18 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 39 p. 5345 - 5347
反应条件
1.1: trimethylsilylazide; tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 70 °C 2.1: triethylamine / dichloromethane / 0.5 h / 0 °C 3.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C 3.2: 18 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 39 p. 5345 - 5347
反应条件
1.1: triethylamine / dichloromethane / 0.5 h / 0 °C 2.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C 2.2: 18 h View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 39 p. 5345 - 5347
反应条件
1: acetic acid; sodium tris(acetoxy)borohydride / water; methanol / 20 °C 2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C View Scheme
参考文献
Berthel, Steven Joseph; Billedeau, Roland Joseph; Brotherton-Pleiss, Christine E.; Firooznia, Fariborz; Gabriel, Stephen Deems; Han, Xiaochun; Hilgenkamp, Ramona; Jaime-Figueroa, Saul; Kocer, Buelent; Lopez-Tapia, Francisco Javier; Lou, Yan; Orzechowski, Lucja; Owens, Timothy D.; Tan, Jenny; Wovkulich, Peter Michael
Patent: US2012/40949 A1, 2012 ;
US 20120040949 A1
反应条件
1: acetic acid; sodium tris(acetoxy)borohydride / water; methanol / 20 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
参考文献
Berthel, Steven Joseph; Billedeau, Roland Joseph; Brotherton-Pleiss, Christine E.; Firooznia, Fariborz; Gabriel, Stephen Deems; Han, Xiaochun; Hilgenkamp, Ramona; Jaime-Figueroa, Saul; Kocer, Buelent; Lopez-Tapia, Francisco Javier; Lou, Yan; Orzechowski, Lucja; Owens, Timothy D.; Tan, Jenny; Wovkulich, Peter Michael
Patent: US2012/40949 A1, 2012 ;
US 20120040949 A1
