sodium methylate in methanol 1 h; Ambient temperature;

1: 82 percent / sodium methoxide / methanol / 1 h / Ambient temperature 2: 90 percent / p-toluenesulfonic acid / dimethylformamide / 3 h / 60 °C 3: 82 percent / pyridine / 52 h / 60 °C 4: 89 percent / 80percent aq. acetic acid / 1.5 h / 70 °C 5: 40 percent / sodium acetate / H2O; 2-methoxy-ethanol / 1.5 h / 120 °C View Scheme

Multi-step reaction with 2 steps 1: 90percent aq. formic acid, 35percent hydrogen peroxide / 1 h / 60 °C2: pyridine / Ambient temperature