N-(1,1-二甲基-2-丙炔-1-基)氨基甲酸1,1-二甲基乙酯合成路线 （共 5 条）
反应条件
in tetrahydrofuran T=20°C; 16 h;
参考文献
Francavilla, Charles; Low, Eddy; Nair, Satheesh; Kim, Bum; Shiau, Timothy P.; Debabov, Dmitri; Celeri, Chris; Alvarez, Nichole; Houchin, Ashley; Xu, Ping; Najafi, Ron; Jain, Rakesh
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 10 p. 2731 - 2734
反应条件
(1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester; potassium carbonate in methanol T=0 - 10°C; 6 h;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2005/19174 A1, 2005 ;
Location in patent: Page/Page column 52-53 ;
反应条件
1: (2-oxo-propyl)-phosphonic acid dimethyl ester With 4-toluenesulfonyl azide; potassium carbonate in acetonitrile T=0°C; 1 h; Inert atmosphere; 2: (1,1-dimethyl-2-oxo-ethyl)-carbamic acid tert-butyl ester in methanol; acetonitrile T=0 - 20°C;
参考文献
Rajagopal, Basker; Chen, Ying-Yu; Chen, Chun-Chi; Liu, Xuan-Yu; Wang, Huei-Ren; Lin, Po-Chiao
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1254 - 1264
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 0.5 h;
参考文献
Rajagopal, Basker; Chen, Ying-Yu; Chen, Chun-Chi; Liu, Xuan-Yu; Wang, Huei-Ren; Lin, Po-Chiao
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1254 - 1264
反应条件
1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C 2: triethylamine / dichloromethane / 4 h / 20 °C View Scheme
参考文献
Rajagopal, Basker; Chen, Ying-Yu; Chen, Chun-Chi; Liu, Xuan-Yu; Wang, Huei-Ren; Lin, Po-Chiao
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1254 - 1264
