chloro-trimethyl-silane; lithium diisopropyl amide in tetrahydrofuran; cyclohexane T=-95°C; Elimination; 0.25 h;

water; lithium diisopropyl amide; methyl iodide Yield given. Multistep reaction. Yields of byproduct given;

1: LiHMDS; CsF / tetrahydrofuran / 2 h / 0 °C 2: 86 percent / LiHMDS / tetrahydrofuran / 2.5 h / -78 - -45 °C 3: 62 percent / TMSCl; LDA / tetrahydrofuran; cyclohexane / 0.25 h / -95 °C View Scheme