2,4-二氟-5-硝基苯酚合成路线 （共 4 条）
反应条件
1: With sulfuric acid; nitric acid T=0°C; 0.25 h; 2: With sodium hydrogencarbonate in methanol T=20°C; 16 h;
参考文献
WO2013/36232 A2, ;
Paragraph 00224 ;
反应条件
iron(III) chloride in water
反应条件
1: Et3N / CH2Cl2 / 2 h / 10 - 20 °C 2: HNO3, H2SO4 / 1 h / 10 - 20 °C 3: NaHCO3, methanol / 16 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 12 p. 1446 - 1450
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate T=50 - 60°C; 27 h;
参考文献
Deciphera Pharmaceuticals, LLC
Patent: US2008/90856 A1, 2008 ;
Location in patent: Page/Page column 35 ;
US 20080090856 A1
