hydrogen; palladium on activated charcoal in ethyl acetate T=50 - 60°C; 27 h;

1: Et3N / CH2Cl2 / 2 h / 10 - 20 °C 2: HNO3, H2SO4 / 1 h / 10 - 20 °C 3: NaHCO3, methanol / 16 h / Ambient temperature 4: 96 percent / H2 / 10percent Pd/C / ethyl acetate / 27 h / 50 - 60 °C View Scheme

1: HNO3, H2SO4 / 1 h / 10 - 20 °C 2: NaHCO3, methanol / 16 h / Ambient temperature 3: 96 percent / H2 / 10percent Pd/C / ethyl acetate / 27 h / 50 - 60 °C View Scheme