4-氰基哌嗪-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
potassium carbonate in acetone T=20°C; 1 h;
参考文献
Institute Of Medicinal Molecular Design, Inc.; ShionogiandCo., Ltd.
Patent: EP2208728 A1, 2010 ;
Location in patent: Page/Page column 33 ;
反应条件
bromocyane; N-ethyl-N,N-diisopropylamine in dichloromethane T=0°C; 1.5 h;
参考文献
GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus; WELLENZOHN, Bernd
Patent: US2013/143870 A1, 2013 ;
Location in patent: Paragraph 0371; 0372; 0373 ;
反应条件
in tetrahydrofuran 2 h; Ambient temperature;
参考文献
Bordner, Jon; Campbell, Simon F.; Palmer, Michael J.; Tute, Michael S.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 1036 - 1039
