1: 0.74 g / trifluoroacetic acid / 1 h / 0 °C 2: diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature 3: trifluoroacetic acid / 1 h / 0 °C 4: diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature 5: trifluoroacetic acid / 1 h / 0 °C 6: diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature 7: H2 / Pd/C 8: trifluoroacetic acid View Scheme

Multi-step reaction with 2 steps 1: 80.4 percent / cyanuric fluoride, pyridine / CH2Cl2 / 1 h / -30 - -20 °C2: 80 percent / diisopropylethylamine / CH2Cl2 / 2 h / Ambient temperature