反应条件
1: EtN(i-Pr)2 / CH2Cl2 / 24 h / Heating
2: OsO4, NaIO4 / diethyl ether; H2O / 7 h
3: LiAlH4 / diethyl ether / 0.5 h / below 10 deg C
4: pyridine / Ambient temperature
5: 75 percent AcOH / 1 h / 30 °C
6: 1.) LDA / 1.) THF, below -60 deg C, 20 min; 2.) THF, below -60 deg C, 30 min
7: NaOAc / 0.67 h / 130 °C
8: 1 percent NaOMe / methanol / 1 h / Ambient temperature
9: 97 percent / Et3N, DMAP / CH2Cl2 / 7 h / below 0 deg C
10: 1.) NaN(TMS)2; 2.) LiAlH4 / 1.) DME, 50 min, reflux; 2.) Et2O, 0 deg C, 1 h
11: DMAP, pyridine / tetrahydrofuran / 24 h / Ambient temperature
12: 84 percent / TMSCl, NaI / acetonitrile / -10 °C
13: 86 percent / sodium naphtalenide / 0.08 h / -70 °C
14: 69 percent / PCC, molecular sieves 3A / CH2Cl2 / 0.5 h / Ambient temperature
15: 1.) hexamethyldisilazane, n-BuLi / 1.) THF, n-hexane, -10 deg C, 10 min; 2.) THF, -70 deg C, 1 h; 3.) THF, -5 to 20 deg C, 5 min
View Scheme
参考文献
Kitahara, Takeshi; Mori, Masataka; Mori, Kenji
Tetrahedron, 1987 , vol. 43, # 12 p. 2689 - 2700
