反应条件
Multi-step reaction with 8 steps 1: 84 percent / pyridinium chlorochromate / CH2Cl2 / 2 h / Ambient temperature2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 2.) -78 deg C, 1 h3: 1.) K2CO3 / 1.) DMF, 100 deg C, 2 h, 2.) 50 deg C, 20 min4: 93 percent / H2 / 5percent rhodium on alumina / ethyl acetate / 13 h / 5320 Torr5: 100 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Ambient temperature6: 1.36 g / triethylamine / CH2Cl2 / 0.08 h / 0 °C7: 80 percent / LiAlH4 / diethyl ether / 0.5 h / Ambient temperature8: 96 percent / 4-(N,N-dimethylamino)pyridine / pyridine / 10 h / Ambient temperature
参考文献
Kametani; Katoh; Fujio; Nogiwa; Tsubuki; Honda Journal of Organic Chemistry, 1988 , vol. 53, # 9 p. 1982 - 1991