3',4',5'-三甲氧基苯乙酮合成路线 （共 90 条）
反应条件
1: KOH / ethanol / 0 °C
2: aq. H2O2; NaOH / 0 - 4 °C
View Scheme
参考文献
Bhat; Dhar; Puri; Saxena; Shanmugavel; Qazi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 12 p. 3177 - 3180
反应条件
1: Br2 / CHCl3
2: betaine / ethanol / 60 °C
View Scheme
参考文献
Nam, Nguyen-Hai; Kim, Yong; You, Young-Jae; Hong, Dong-Ho; Kim, Hwan-Mook; Ahn, Byung-Zun
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 23 p. 3073 - 3076
反应条件
1: 85 percent / NaOH / methanol / 18 h / 25 - 30 °C
2: 80 percent / aq. NaOH; aq. H2O2 / methanol; acetone / 0.75 h / 20 - 25 °C
3: 87 percent / NaOH / H2O; ethanol / 4 h / Heating
4: 89 percent / NaIO4 / acetone; acetic acid; H2O / 7 h / 25 °C
5: 95 percent / HCOONH4 / Pd/C / methanol / 1 h / Heating
View Scheme
参考文献
xxx
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2000 , vol. 39, # 11 p. 817 - 821
反应条件
1: formyl formic acid With acetic anhydride; ytterbium(III) triflate
T=20°C; 0.166667 h;
2: 1-(3,4,5-trimethoxyphenyl)ethanone With acetic acid in acetic acid
T=140°C; 1 h; Microwave irradiationSealed tube;
参考文献
Tolstoluzhsky, Nikita; Nikolaienko, Pavlo; Gorobets, Nikolay; Van Der Eycken, Erik V.; Kolos, Nadezhda
European Journal of Organic Chemistry, 2013 , # 24 p. 5364 - 5369
反应条件
1: 56 percent / 3 h / 95 °C / 50 Torr
2: 70 percent / conc. HCl / acetic acid / 1.5 h / Heating
View Scheme
参考文献
Bianchi, Mario; Butti, Alina; Christidis, Yani; Perronnet, Jacques; Barzaghi, Fernando; et al.
European Journal of Medicinal Chemistry, 1988 , vol. 23, p. 45 - 52
反应条件
1.1: acetic anhydride; ytterbium(III) triflate / 0.17 h / 20 °C
1.2: 1 h / 140 °C / |Microwave irradiation; |Sealed tube
2.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 25 °C
View Scheme
参考文献
Tolstoluzhsky, Nikita; Nikolaienko, Pavlo; Gorobets, Nikolay; Van Der Eycken, Erik V.; Kolos, Nadezhda
European Journal of Organic Chemistry, 2013 , # 24 p. 5364 - 5369
反应条件
pyridine; selenium(IV) oxide
3 h; Reflux;
参考文献
Peifer, Christian; Selig, Roland; Kinkel, Katrin; Ott, Dimitri; Totzke, Frank; Schaechtele, Christoph; Heidenreich, Regina; Roecken, Martin; Schollmeyer, Dieter; Laufer, Stefan
Journal of Medicinal Chemistry, 2008 , vol. 51, # 13 p. 3814 - 3824
反应条件
sodium hydride in toluene
T=65°C; Wittig-Horner Reaction; 12 h; Inert atmosphere;
参考文献
Reddy, Alavala Gopi Krishna; Mahendar, Lodi; Satyanarayana, Gedu
Synthetic Communications, 2014 , vol. 44, # 14 p. 2076 - 2087
反应条件
sodium hydride in tetrahydrofuran
T=20°C; 72 h;
参考文献
Gangjee, Aleem; Yang, Jie; Queener, Sherry F.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8341 - 8351
反应条件
hydrogenchloride; amalgamated zinc
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1931 , vol. <2> 129, p. 278
Full Text Show Details
Mauthner
Magyar chem. Folyoirat, 1932 , vol. 38, p. 8,9
Chem. Zentralbl., 1932 , vol. 103, # I p. 2710
