反应条件
1.1: toluene-4-sulfonic acid / benzene / 24 h / 80 °C / Inert atmosphere
2.1: ammonia; lithium / tetrahydrofuran / 1 h / -30 °C / Inert atmosphere
2.2: 3 h / Reflux
3.1: ozone / tetrahydrofuran / -78 °C / Inert atmosphere
3.2: 4 h / 25 °C / Inert atmosphere
4.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere
5.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 18 h / 25 °C / Inert atmosphere
6.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
6.2: 15 h / 65 °C / Inert atmosphere
7.1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 3620.13 Torr / Inert atmosphere
8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 25 °C / Inert atmosphere
9.1: hydrogenchloride / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere
10.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
10.2: 18 h / 25 °C / Inert atmosphere
11.1: rhodium(III) trichloride hydrate / ethanol / 18 h / Inert atmosphere; Reflux
12.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 15 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Ling, Taotao; Xu, Jing; Smith, Ryan; Ali, Abbas; Cantrell, Charles L.; Theodorakis, Emmanuel A.
Tetrahedron, 2011 , vol. 67, # 17 p. 3023 - 3029