N,N-二甲基-4-联苯胺合成路线 （共 82 条）
反应条件
1: N,N-dimethyl-4-phenylaniline With lithium in tetrahydrofuran T=25°C; 2 h; 2: 1-bromo-butane in tetrahydrofuran T=25°C; 2 h;
参考文献
Azzena, Ugo; Cattari, Manuela; Melloni, Giovanni; Pisano, Luisa
Synthesis, 2003 , # 18 p. 2811 - 2814
反应条件
1: N,N-dimethyl-4-phenylaniline With lithium in tetrahydrofuran T=25°C; 2 h; 2: methyl iodide in tetrahydrofuran T=25°C; 2 h;
参考文献
Azzena, Ugo; Cattari, Manuela; Melloni, Giovanni; Pisano, Luisa
Synthesis, 2003 , # 18 p. 2811 - 2814
反应条件
potassium phosphate; naphthidine di(radical cation)s-stabilized Pd nanoparticles in 1,4-dioxane
T=80°C; Suzuki-Miyaura cross-coupling reaction; 8 h;
参考文献
Desmarets, Christophe; Omar-Amrani, Rafik; Walcarius, Alain; Lambert, Jacques; Champagne, Benoit; Fort, Yves; Schneider, Raphael
Tetrahedron, 2008 , vol. 64, # 2 p. 372 - 381
反应条件
C32H26ClN2NiP in tetrahydrofuran
T=30°C; Kumada Cross-Coupling; 24 h; Schlenk techniqueInert atmosphere;
参考文献
Zhang, Xue-Qi; Wang, Zhong-Xia
Synlett, 2013 , vol. 24, # 16 art. no. ST-2013-W0528-L, p. 2081 - 2084
反应条件
1: 4-bromo-N,N-dimethyl-aniline With (nBu)3MgLi in tetrahydrofuran
T=0°C; 0.0833333 h;
2: bromobenzene With Cl2Ni(1,2-bis(diphenylphosphino)ethane) in tetrahydrofuran
T=0°C; Kumada-Corriu cross-coupling; Further stages.;
参考文献
Lau, Stephen Y. W.; Hughes, Greg; O'Shea, Paul D.; Davies, Ian W.
Organic Letters, 2007 , vol. 9, # 11 p. 2239 - 2242
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine in tetrahydrofuran; toluene
T=20°C; 1 h; Schlenk techniqueInert atmosphere;
参考文献
Giannerini, Massimo; Fananas-Mastral, Martin; Feringa, Ben L.
Nature Chemistry, 2013 , vol. 5, # 8 p. 667 - 672
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium lauryl sulfate; potassium carbonate; p-toluenesulfonyl chloride in water
T=60°C; Suzuki Coupling;
参考文献
Liu, Jin-Biao; Zhou, He-Ping; Peng, Yi-Yuan
Tetrahedron Letters, 2014 , vol. 55, # 17 p. 2872 - 2875
反应条件
1: 4-bromo-N,N-dimethyl-aniline With lithium
2: With zinc(II) chloride
3: chlorobenzene With nickel phosphine amido pincer complex in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=70°C; Negishi cross-coupling; 12 h; Further stages.;
参考文献
Wang, Li; Wang, Zhong-Xia
Organic Letters, 2007 , vol. 9, # 21 p. 4335 - 4338
反应条件
potassium phosphate; Ni(PCy3)2Cl2 in toluene
T=110°C; Suzuki-Miyaura coupling reaction; 24 h; Inert atmosphere;
参考文献
Quasdorf, Kyle W.; Antoft-Finch, Aurora; Liu, Peng; Silberstein, Amanda L.; Komaromi, Anna; Blackburn, Tom; Ramgren, Stephen D.; Houk; Snieckus, Victor; Garg, Neil K.
Journal of the American Chemical Society, 2011 , vol. 133, # 16 p. 6352 - 6363
反应条件
1-[2-(diphenylphosphino)phenyl]ethanol; bis(acetylacetonate)nickel(II) in diethyl ether
T=20°C; 5 h;
参考文献
Yoshikai, Naohiko; Mashima, Hiroko; Nakamura, Eiichi
Journal of the American Chemical Society, 2005 , vol. 127, # 51 p. 17978 - 17979
