N,N-二甲基-4-联苯胺合成路线 （共 82 条）
反应条件
lithium tert-butylate; [NiCl2(PMe3)2] in tetrahydrofuran
T=60°C; 6 h;
参考文献
Miller, Joseph A.
Tetrahedron Letters, 2001 , vol. 42, # 40 p. 6991 - 6993
反应条件
1: Bromure de phenyl magnesium With indium(III) chloride in tetrahydrofuran
T=25°C;
2: 4-iodo-N,N-dimethylaniline With tris-(dibenzylideneacetone)dipalladium(0); trifuran-2-yl-phosphane in tetrahydrofuran; water
2 h; Heating; Further stages.;
参考文献
Takami, Kazuaki; Yorimitsu, Hideki; Shinokubo, Hiroshi; Matsubara, Seijiro; Oshima, Koichiro
Organic Letters, 2001 , vol. 3, # 13 p. 1997 - 1998
反应条件
tetrabutyl ammonium fluoride; bis(acetylacetonato) palladium; 3,9-bis(2,4-tBu-PhO)tetraoxa-3,9-diphosphaspiro[5.5]undecane in xylene
T=80°C; Hiyama coupling;
参考文献
Ju, Jinhun; Nam, Hyungoog; Jung, Hyun Min; Lee, Sunwoo
Tetrahedron Letters, 2006 , vol. 47, # 49 p. 8673 - 8678
反应条件
1: 4-bromo-N,N-dimethyl-aniline With n-butyllithium in tetrahydrofuran; hexane
T=-75°C; 1 h;
2: triphenylborane in tetrahydrofuran; hexane
T=-75°C; 1 h;
3: With oxygen; [VO(OEt)Cl2] in dichloromethane; acetonitrile
12 h; Heating;
参考文献
Mizuno, Hidenori; Sakurai, Hidehiro; Amaya, Toru; Hirao, Toshikazu
Chemical Communications, 2006 , # 48 p. 5042 - 5044
反应条件
Ni(Cl){2-(Ph2P)C6H4NCH(Ph)P(O)Ph2} in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=25°C; Negishi coupling reaction; 12 h; Inert atmosphere;
参考文献
Liu, Ning; Wang, Li; Wang, Zhong-Xia
Chemical Communications, 2011 , vol. 47, # 5 p. 1598 - 1600
反应条件
sodium hydroxide; [PdCl2(P(3,4-(18-crown-6)-phenyl)2(C6H5))2]
T=140°C; 5 h;
参考文献
Gordillo, Alvaro; De Jesus, Ernesto; Lopez-Mardomingo, Carmen
Organic Letters, 2006 , vol. 8, # 16 p. 3517 - 3520
反应条件
Ni(PCy3)2Cl2; tri-cyclo-hexyl-phosphine in diethyl ether
T=20°C; Kumada coupling; 2 h; Inert atmosphere;
参考文献
Guan, Bing-Tao; Lu, Xing-Yu; Zheng, Yang; Yu, Da-Gang; Wu, Tong; Li, Kun-N; Li, Bi-Jie; Shi, Zhang-Jie
Organic Letters, 2010 , vol. 12, # 2 p. 396 - 399
反应条件
K3PO4*7H2O in tetrahydrofuran
T=60°C; Suzuki coupling; 24 h; Inert atmosphere;
参考文献
Wu, Lei; Ling, Jie; Wu, Zong-Quan
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 9 p. 1452 - 1456
反应条件
1-methyl-pyrrolidin-2-one; tetrakis(triphenylphosphine) palladium(0)
T=80°C; 3 h;
参考文献
Shimada, Shigeru; Yamazaki, Osamu; Tanaka, Toshifumi; Rao, Maddali L. N.; Suzuki, Yohichi; Tanaka, Masato
Angewandte Chemie - International Edition, 2003 , vol. 42, # 16 p. 1845 - 1848
反应条件
1: phenyl-magnesium chloride With titanium tetraethoxide in tetrahydrofuran
T=0°C;
2: 4-bromo-N,N-dimethyl-aniline With P[2,4,6-(OMe)3C6H2]3 in tetrahydrofuran
T=25°C; 16 h; Further stages.;
参考文献
Manolikakes, Georg; Dastbaravardeh, Navid; Knochel, Paul
Synlett, 2007 , # 13 p. 2077 - 2080
