N,N-二甲基-4-联苯胺合成路线 （共 82 条）
反应条件
triethylamine in 2,2,2-trifluoroethanol
5 h; Photolysis;
参考文献
De Carolis, Marco; Protti, Stefano; Fagnoni, Maurizio; Albini, Angelo
Angewandte Chemie - International Edition, 2005 , vol. 44, # 8 p. 1232 - 1236
反应条件
triethylamine in 2,2,2-trifluoroethanol
Photolysis;
参考文献
De Carolis, Marco; Protti, Stefano; Fagnoni, Maurizio; Albini, Angelo
Angewandte Chemie - International Edition, 2005 , vol. 44, # 8 p. 1232 - 1236
反应条件
caesium carbonate in 2,2,2-trifluoroethanol
3 h; UV-irradiation;
参考文献
Dichiarante, Valentina; Salvaneschi, Andrea; Protti, Stefano; Dondi, Daniele; Fagnoni, Maurizio; Albini, Angelo
Journal of the American Chemical Society, 2007 , vol. 129, # 51 p. 15919 - 15926
反应条件
1: With 1-[2-(diphenylphosphino)phenyl]ethanol; bis(acetylacetonate)nickel(II) in diethyl ether
5 h;
2: With methanol in diethyl ether
Product distribution / selectivity;
参考文献
THE UNIVERSITY OF TOKYO
Patent: WO2006/85628 A1, 2006 ;
Location in patent: Page/Page column 32-34 ;
反应条件
1: 4-Me2NC6H4MgX, X = halide With zinc(II) chloride in tetrahydrofuran
T=25°C; 0.25 h; Inert atmosphere;
2: bromobenzene With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 35 p. 8996 - 9003
反应条件
1: PhMgX, X = halide With zinc(II) chloride in tetrahydrofuran
T=25°C; 0.25 h; Inert atmosphere;
2: 4-bromo-N,N-dimethyl-aniline With [(C10H13-1,3-(CH2P(Cy)2)2)Pd(Cl)] in tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction; Inert atmosphereResealed tube;
参考文献
Gerber, Roman; Blacque, Olivier; Frech, Christian M.
Dalton Transactions, 2011 , vol. 40, # 35 p. 8996 - 9003
反应条件
1: methyl-phenyl-thioether With C30H21F6N2NiO2P in tetrahydrofuran
Schlenk techniqueInert atmosphere;
2: 4-bromo-N,N-dimethyl-aniline With magnesium; lithium chloride in tetrahydrofuran
T=70°C; 24 h;
参考文献
Someya, Chika I.; Weidauer, Maik; Enthaler, Stephan
Catalysis Letters, 2013 , vol. 143, # 5 p. 424 - 431
反应条件
tetrakis(triphenylphosphine) palladium(0) in various solvent(s)
T=80°C; 5 h; Title compound not separated from byproducts;
参考文献
Catellani, Marta; Chiusoli, Gian Paolo; Fornasari, Vilma
Gazzetta Chimica Italiana, 1990 , vol. 120, p. 779 - 781
反应条件
Pd((1E,4E)-1,5-diphenylpenta-1,4-dien-3-one)2; potassium hexamethylsilazane; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in 1,4-dioxane
T=100°C; 2 h; other palladium ligands; Product distribution;
参考文献
Shaughnessy, Kevin H.; Hamann, Blake C.; Hartwig, John F.
Journal of Organic Chemistry, 1998 , vol. 63, # 19 p. 6546 - 6553
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate in tetrahydrofuran; water
T=60°C; Suzuki-Miyaura reaction; 24 h; Inert atmosphere;
参考文献
Reznicek, Tomas; Dostal, Libor; Ruzicka, Ales; Kulhanek, Jiri; Bures, Filip; Jambor, Roman
Applied Organometallic Chemistry, 2011 , vol. 25, # 3 p. 173 - 179
