5-[(4-氟苯基)甲基]-3,4-二氢-2H-吡咯合成路线 （共 2 条）
反应条件
1: 4-bromomethyl-fluorobenzene With magnesium in diethyl ether T=40°C; 2 h; 2: 4-chloro-n-butyronitrile in diethyl ether 3: in toluene T=95°C; 2 h;
参考文献
MERCKLE GMBH
Patent: EP1246825 B1, 2003 ;
Location in patent: Page 25; 26 ;
反应条件
1: 4-chloro-n-butyronitrile; p-fluorobenzylmagnesium halide 2: Heating;
参考文献
Ulbrich, Holger; Fiebich, Bernd; Dannhardt, Gerd
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 12 p. 953 - 959
