sodium hydroxide in tetrahydrofuran; water T=20°C; 2 h;

1: 82 percent / (PhCN)2PdCl2, Ph3P, copper(II) acetate hydrate, diisopropylamine / 1.) RT, 4 h, 2.) reflux, 1 h 2: 91 percent / KOH, H2O / methanol / 0.33 h / Ambient temperature View Scheme

1: 4-(N,N-dimethlyamino)pyridine; 2,6-dimethylpyridine / dichloromethane; tetrahydrofuran / 7.25 h / -78 - 0 °C / |Molecular sieve; |Inert atmosphere 2: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine; piperidine / |Molecular sieve; |Inert atmosphere; |Reflux 3: sodium hydroxide / tetrahydrofuran; water / 2 h / 20 °C View Scheme

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine; piperidine / |Molecular sieve; |Inert atmosphere; |Reflux 2: sodium hydroxide / tetrahydrofuran; water / 2 h / 20 °C View Scheme