2-氰基-2-(2-硝基苯基)乙酸甲酯合成路线 （共 4 条）
反应条件
sodium hydride in tetrahydrofuran Heating;
参考文献
Journal of Organic Chemistry, , vol. 69, # 13 p. 4429 - 4432
反应条件
diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate; palladium 10 on activated carbon in ethanol 10 h; RefluxInert atmosphere; chemoselective reaction;
参考文献
Xing, Ruiguang; Tian, Qiuping; Liu, Qiang; Li, Yanan
Chinese Journal of Chemistry, 2013 , vol. 31, # 2 p. 263 - 266
反应条件
1: 79 percent / potassium carbonate / tetrahydrofuran / 36 h / 0 - 20 °C
2: 60 percent / NaCl / dimethylsulfoxide / 0.33 h / 150 °C
3: 80 percent / LiOH / dimethylformamide; H2O / 0 - 20 °C
4: 88 percent / copper; quinoline / 0.33 h / 220 °C
5: 98 percent / DIBAL-H / toluene / 0.33 h / -78 °C
View Scheme
参考文献
Selvakumar; Rajulu, G. Govinda
Journal of Organic Chemistry, 2004 , vol. 69, # 13 p. 4429 - 4432
反应条件
1: zinc; acetic acid / toluene / 40 - 85 °C
2: 2 h / 220 °C
3: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 2 h / Reflux
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参考文献
GLAXOSMITHKLINE LLC; HAMMOND, Marlys; ZHAO, Yongdong
Patent: WO2011/56739 A1, 2011 ;
