2-氨基吲哚-3-羧酸甲酯合成路线 （共 4 条）
反应条件
diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate; palladium 10 on activated carbon in ethanol 10 h; RefluxInert atmosphere; chemoselective reaction;
参考文献
Xing, Ruiguang; Tian, Qiuping; Liu, Qiang; Li, Yanan
Chinese Journal of Chemistry, 2013 , vol. 31, # 2 p. 263 - 266
反应条件
1: With potassium carbonate; L-proline in dimethyl sulfoxide Ullmann type coupling; 0.25 h; Inert atmosphere; 2: With copper(l) iodide in dimethyl sulfoxide T=60°C; Ullmann type coupling; 12 h; Inert atmosphere;
参考文献
Yang, Xiaobo; Fu, Hua; Qiao, Renzhong; Jiang, Yuyang; Zhao, Yufen
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 6 p. 1035 - 1038
反应条件
1: With potassium carbonate; L-proline in dimethyl sulfoxide Ullmann type coupling; 0.25 h; Inert atmosphere; 2: With copper(l) iodide in dimethyl sulfoxide T=60°C; Ullmann type coupling; 12 h; Inert atmosphere;
参考文献
Yang, Xiaobo; Fu, Hua; Qiao, Renzhong; Jiang, Yuyang; Zhao, Yufen
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 6 p. 1035 - 1038
反应条件
1: 2 h / 220 °C
2: N-ethyl-N,N-diisopropylamine; trichlorophosphate / acetonitrile / 2 h / Reflux
View Scheme
参考文献
GLAXOSMITHKLINE LLC; HAMMOND, Marlys; ZHAO, Yongdong
Patent: WO2011/56739 A1, 2011 ;
