hydrolysis;

1: 1.) NaH / 1.) DMF, r.t., 2.) r.t. 2: NaBH4 / methanol; tetrahydrofuran / -15 °C 3: p-TsOH*H2O / toluene / 0.5 h / Heating 4: 1.) POCl3 / 1.) CH2Cl2, 30 min, 2.) CH2Cl2, reflux, 2.5 h 5: NaBH4 / tetrahydrofuran 6: pyridine, SOCl2 / CH2Cl2 / Ambient temperature 7: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, 15 min 8: 78 percent / hydrolysis View Scheme

1: 1.) POCl3 / 1.) CH2Cl2, 30 min, 2.) CH2Cl2, reflux, 2.5 h 2: NaBH4 / tetrahydrofuran 3: pyridine, SOCl2 / CH2Cl2 / Ambient temperature 4: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, 15 min 5: 78 percent / hydrolysis View Scheme

1: p-TsOH*H2O / toluene / 0.5 h / Heating 2: 1.) POCl3 / 1.) CH2Cl2, 30 min, 2.) CH2Cl2, reflux, 2.5 h 3: NaBH4 / tetrahydrofuran 4: pyridine, SOCl2 / CH2Cl2 / Ambient temperature 5: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, 15 min 6: 78 percent / hydrolysis View Scheme