3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基4-甲基苯磺酸酯合成路线 （共 6 条）
→
113823-56-63,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基4-甲基苯磺酸酯
反应条件
triethylamine in dichloromethane T=0 - 20°C; Tosylation;
参考文献
Elshani, Sadik; Kobzar, Evgeny; Bartsch, Richard A.
Tetrahedron, 2000 , vol. 56, # 21 p. 3291 - 3301
113823-56-63,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基4-甲基苯磺酸酯
→
反应条件
1.1: 93 percent / LiBr / acetone / 7 h / Heating 2.1: Mg; I2 / tetrahydrofuran / 4 h / Heating 2.2: tetrahydrofuran / -6 - 24 °C View Scheme
参考文献
Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Journal of Organic Chemistry, 2002 , vol. 67, # 6 p. 1781 - 1785
113823-56-63,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基4-甲基苯磺酸酯
→
344580-04-72,2,2-三氟乙基4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一烷酸酯
反应条件
1.1: 93 percent / LiBr / acetone / 7 h / Heating 2.1: Mg; I2 / tetrahydrofuran / 4 h / Heating 2.2: tetrahydrofuran / -6 - 24 °C 3.1: 84 percent / PCl5 / diethyl ether / 4 h / Heating 4.1: 91 percent / DMAP; pyridine / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Angewandte Chemie - International Edition, 2001 , vol. 40, # 13 p. 2492 - 2494
113823-56-63,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基4-甲基苯磺酸酯
→
反应条件
lithium bromide in acetone 7 h; Heating;
参考文献
Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Journal of Organic Chemistry, 2002 , vol. 67, # 6 p. 1781 - 1785
113823-56-63,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基4-甲基苯磺酸酯
→
反应条件
sodium azide in N,N-dimethyl-formamide; benzene T=70°C; 20 h;
参考文献
Zhu, Yi-Wei; Yi, Wen-Bin; Cai, Chun
Journal of Fluorine Chemistry, 2011 , vol. 132, # 1 p. 71 - 74
113823-56-63,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基4-甲基苯磺酸酯
→
89373-67-14,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-十七氟十一酰氯
反应条件
1.1: 93 percent / LiBr / acetone / 7 h / Heating
2.1: Mg; I2 / tetrahydrofuran / 4 h / Heating
2.2: tetrahydrofuran / -6 - 24 °C
3.1: 84 percent / PCl5 / diethyl ether / 4 h / Heating
View Scheme
参考文献
Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Angewandte Chemie - International Edition, 2001 , vol. 40, # 13 p. 2492 - 2494
