甲基 2-甲基-2-丙基 (2S)-氨基(4-碘苄基)丙二酸酯合成路线 （共 11 条）
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide T=0 - 20°C; Inert atmosphere;
参考文献
Synlett, , # 20 art. no. G30610ST, p. 3081 - 3085
参考文献
Journal of the American Chemical Society, , vol. 114, # 19 p. 7597 - 7598
反应条件
4-methyl-morpholine in dichloromethane 5 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 59, # 15 p. 4206 - 4210
反应条件
1: 53 percent / I2, NaIO3, conc. H2SO4 / acetic acid / 21 h / 70 °C 2: 92 percent / SOCl2 / 2 h / Heating 3: 77 percent / N-methylmorpholine / CH2Cl2 / 5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 15 p. 4206 - 4210
反应条件
in methanol; diethyl ether; benzene T=20°C; 1 h; Product distribution / selectivity;
参考文献
US2008/33024 A1, ;
Page/Page column 7; 12; 16 ;
US 20080033024 A1
反应条件
1: 92 percent / SOCl2 / 2 h / Heating 2: 77 percent / N-methylmorpholine / CH2Cl2 / 5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 15 p. 4206 - 4210
反应条件
sodium hydrogencarbonate in tetrahydrofuran
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 5 p. 1976 - 1979
反应条件
in tetrahydrofuran; methanol; diethyl ether T=0°C;
参考文献
Tetrahedron, , vol. 53, # 32 p. 11171 - 11178
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Miyaura reagent in dimethyl sulfoxide T=80°C; 18 h; other borane-reagent, solvents, temperature, and catalysts; Product distribution;
参考文献
Firooznia; Gude; Chan; Marcopulos; Satoh
Tetrahedron Letters, 1999 , vol. 40, # 2 p. 213 - 216
反应条件
1: 88 percent / PdCl2; PPh3 / dimethylformamide / 5 h / 90 °C 2: 100 percent / aq. NaOH / methanol / 20 °C View Scheme
参考文献
Morera, Enrico; Ortar, Giorgio
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 16 p. 1815 - 1818
