2-(4-甲基-1H-1,4-二氮杂环庚烷-1-基)-N-[(5-甲基-2-吡嗪基)甲基]-5-氧代-5H-苯并噻唑并[3,2-a][1,8]萘啶-6-甲酰胺合成路线 （共 4 条）
反应条件
AlCl3, aluminium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=0 - 20°C;
参考文献
Schwaebe, Michael K.; Ryckman, David M.; Nagasawa, Johnny Y.; Pierre, Fabrice; Vialettes, Anne; Haddach, Mustapha
Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1096 - 1100
反应条件
1.1: acetonitrile / 4 h / Reflux 2.1: AlCl3, aluminium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / -5 - 5 °C 2.2: 1 h / -5 - 20 °C View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 3, # 7 p. 602 - 606
反应条件
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C 2.1: triethylamine; magnesium chloride / acetonitrile / 0.25 h / -10 - 0 °C 2.2: 0.25 h 2.3: 1.5 h / Reflux 3.1: acetonitrile / 4 h / Reflux 4.1: AlCl3, aluminium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / -5 - 5 °C 4.2: 1 h / -5 - 20 °C View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 3, # 7 p. 602 - 606
反应条件
1.1: triethylamine; magnesium chloride / acetonitrile / 0.25 h / -10 - 0 °C 1.2: 0.25 h 1.3: 1.5 h / Reflux 2.1: acetonitrile / 4 h / Reflux 3.1: AlCl3, aluminium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / -5 - 5 °C 3.2: 1 h / -5 - 20 °C View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 3, # 7 p. 602 - 606
