N-(3-碘吡啶-2-基)棕榈酰胺合成路线 （共 4 条）
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane T=-78 - -55°C; 1 h; 2: With iodine in tetrahydrofuran; hexane T=-65 - 0°C; 2 h;
参考文献
CB Research and Development, Inc.
Patent: US2006/183758 A1, 2006 ;
Location in patent: Page/Page column 8 ;
反应条件
1: 1.) tert-BuOK / 1.) liq. NH3, reflux, 5 min, 2.) irradiation 2: 90 percent / 3 N HCl / 4 h / 90 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 12 p. 2740 - 2744
反应条件
1: With sulfuric acid; water 1 h; Heating / reflux; 2: With sodium hydroxide; sodium hydrogencarbonate in water T=20°C;
参考文献
GRUNENTHAL GMBH
Patent: US2009/156593 A1, 2009 ;
Location in patent: Page/Page column 17 ;
反应条件
1: 1.) tert-BuOK / 1.) liq. NH3, reflux, 5 min, 2.) irradiation 2: 3 N HCl / 4 h / 90 °C View Scheme
参考文献
Estel, L.; Marsais, F.; Queguiner, G.
Journal of Organic Chemistry, 1988 , vol. 53, # 12 p. 2740 - 2744
