1: 95 percent / NaOAc, NH2OH*HCl / ethanol; H2O / 1.) reflux, 5 h, 2.) room temperature, overnoght 2: 80 percent / HCl, H2 / 5percent Pd/C / ethanol / 4 h / 2068.6 Torr / Ambient temperature 3: 90 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 4: 94 percent / 18 h / Ambient temperature 5: 98 percent / 5percent K2CO3 / methanol / 2 h / Heating 6: 64 percent / BF3*Et2O / CH2Cl2 / 16 h 7: 97 percent / 1N HCl / methanol / 24 h / 25 °C 8: 66 percent / H2O, paraformaldehyde / tetrahydrofuran / 2 h / Heating 9: TiCl4 / CH2Cl2; diethyl ether / 0.5 h / -78 °C 10: 10percent aq. NaOH / ethanol / 2 h / Heating View Scheme

1: 80 percent / HCl, H2 / 5percent Pd/C / ethanol / 4 h / 2068.6 Torr / Ambient temperature 2: 90 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 3: 94 percent / 18 h / Ambient temperature 4: 98 percent / 5percent K2CO3 / methanol / 2 h / Heating 5: 64 percent / BF3*Et2O / CH2Cl2 / 16 h 6: 97 percent / 1N HCl / methanol / 24 h / 25 °C 7: 66 percent / H2O, paraformaldehyde / tetrahydrofuran / 2 h / Heating 8: TiCl4 / CH2Cl2; diethyl ether / 0.5 h / -78 °C 9: 10percent aq. NaOH / ethanol / 2 h / Heating View Scheme

1: 96 percent / LDA / tetrahydrofuran; cyclohexane / 1.) -5 deg C, 2 h, 2.) room temperature, 18 h 2: 97 percent / H2SO4 / 2 h / Heating 3: 92 percent / NaBH4, CH3OH / tetrahydrofuran / 60 - 70 °C 4: BF3*Et2O / toluene / -15 °C 5: 10percent aq. NaOH / ethanol / 2 h / Heating View Scheme

1: 96 percent / LDA / tetrahydrofuran; cyclohexane / 1.) -5 deg C, 2 h, 2.) room temperature, 18 h 2: 97 percent / H2SO4 / 2 h / Heating 3: 92 percent / NaBH4, CH3OH / tetrahydrofuran / 60 - 70 °C 4: BF3*Et2O / toluene / -15 °C 5: 10percent aq. NaOH / ethanol / 2 h / Heating View Scheme

1: 69 percent / LDA / tetrahydrofuran; cyclohexane / 3 h / -78 °C 2: 92 percent / NaBH4, CH3OH / tetrahydrofuran / 60 - 70 °C 3: BF3*Et2O / toluene / -15 °C 4: 10percent aq. NaOH / ethanol / 2 h / Heating View Scheme

1: 64 percent / BF3*Et2O / CH2Cl2 / 16 h 2: 97 percent / 1N HCl / methanol / 24 h / 25 °C 3: 66 percent / H2O, paraformaldehyde / tetrahydrofuran / 2 h / Heating 4: TiCl4 / CH2Cl2; diethyl ether / 0.5 h / -78 °C 5: 10percent aq. NaOH / ethanol / 2 h / Heating View Scheme

1: 21 g / LDA / tetrahydrofuran; cyclohexane / 1.) 0 deg C, 1 h, 2.) reflux, 20 min 2: LiAlH4 / tetrahydrofuran / 1.5 h / Heating 3: BF3*Et2O / toluene / -15 °C 4: 10percent aq. NaOH / ethanol / 2 h / Heating View Scheme

1: 21 g / LDA / tetrahydrofuran; cyclohexane / 1.) 0 deg C, 1 h, 2.) reflux, 20 min 2: LiAlH4 / tetrahydrofuran / 1.5 h / Heating 3: BF3*Et2O / toluene / -15 °C 4: 10percent aq. NaOH / ethanol / 2 h / Heating View Scheme

1: 94 percent / 18 h / Ambient temperature 2: 98 percent / 5percent K2CO3 / methanol / 2 h / Heating 3: 64 percent / BF3*Et2O / CH2Cl2 / 16 h 4: 97 percent / 1N HCl / methanol / 24 h / 25 °C 5: 66 percent / H2O, paraformaldehyde / tetrahydrofuran / 2 h / Heating 6: TiCl4 / CH2Cl2; diethyl ether / 0.5 h / -78 °C 7: 10percent aq. NaOH / ethanol / 2 h / Heating View Scheme

1: 97 percent / H2SO4 / 2 h / Heating 2: 92 percent / NaBH4, CH3OH / tetrahydrofuran / 60 - 70 °C 3: BF3*Et2O / toluene / -15 °C 4: 10percent aq. NaOH / ethanol / 2 h / Heating View Scheme