9-((2-膦酰基甲氧基)乙基)鸟嘌呤合成路线 （共 9 条）
反应条件
hydrogenchloride in water
T=130 - 140°C; Microwave irradiationSealed tube;
参考文献
Jansa, Petr; Baszczynski, Ondrej; Prochazkova, Eliska; Dracinsky, Martin; Janeba, Zlatko
Green Chemistry, 2012 , vol. 14, # 8 p. 2282 - 2288
反应条件
in water; N,N-dimethyl-formamide; acetone
参考文献
Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic; Rega Stichting v.z.w.
Patent: US5650510 A1, 1997 ;
反应条件
hydrogenchloride
6 h; Heating;
参考文献
Yu; Bronson; Yang; Patick; Alam; Brankovan; Datema; Hitchcock; Martin
Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 2958 - 2969
反应条件
water in water-d2
T=20°C; pH=7.4; aq. phosphate buffer;
参考文献
Elbert, Tomas; Brehova, Petra; Holy, Antonin
Collection of Czechoslovak Chemical Communications, 2010 , vol. 75, # 7 p. 757 - 766
反应条件
trimethylsilyl bromide in N,N-dimethyl-formamide
T=22°C; 8 h;
参考文献
Franchetti; Abu Sheikha; Cappellacci; Messini; Grifantini; Loi; De Montis; Spiga; La Colla
Nucleosides and Nucleotides, 1994 , vol. 13, # 8 p. 1707 - 1719
反应条件
1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, 80 deg C, 5 h
2: 100 percent / bromotrimethylsilane / dimethylformamide / 14 h / Ambient temperature
3: 70 percent / 10percent aq. HCl / 6 h / Heating
View Scheme
参考文献
Yu; Bronson; Yang; Patick; Alam; Brankovan; Datema; Hitchcock; Martin
Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 2958 - 2969
反应条件
1: 41 percent / Cs2CO3 / dimethylsulfoxide / 4 h / 80 °C
2: 88 percent / Me3SiBr / dimethylformamide / 8 h / 22 °C
View Scheme
参考文献
Franchetti; Abu Sheikha; Cappellacci; Messini; Grifantini; Loi; De Montis; Spiga; La Colla
Nucleosides and Nucleotides, 1994 , vol. 13, # 8 p. 1707 - 1719
反应条件
DL-threo-1,4-dimercapto-2,3-butanediol; water
T=37°C; pH=6.8; Enzyme kinetics;
参考文献
Schinkmanova, Marketa; Votruba, Ivan; Shibata, Riri; Han, Bin; Liu, Xiaohong; Cihlar, Tomas; Holy, Antonin
Collection of Czechoslovak Chemical Communications, 2008 , vol. 73, # 2 p. 275 - 291
反应条件
DL-threo-1,4-dimercapto-2,3-butanediol; water
T=37°C; pH=6.8; Enzyme kinetics;
参考文献
Schinkmanova, Marketa; Votruba, Ivan; Shibata, Riri; Han, Bin; Liu, Xiaohong; Cihlar, Tomas; Holy, Antonin
Collection of Czechoslovak Chemical Communications, 2008 , vol. 73, # 2 p. 275 - 291
