(S)-3-(甲基氨基)-1-苯丙醇合成路线 （共 40 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1 h; Heating;
参考文献
Kamal, Ahmed; Khanna; Ramu
Tetrahedron Asymmetry, 2002 , vol. 13, # 18 p. 2039 - 2051
反应条件
1: LiAlH4 / tetrahydrofuran / 5 h / Heating 2: 41 percent / Et3N / CH2Cl2 / 2 h / 23 °C 3: (-)-sparteine; O2; Molecular sieves 3A / Pd(nbd)Cl2 / toluene / 24 h / 80 °C / 760.05 Torr 4: 78 percent / LiAlH4 / tetrahydrofuran / 5.5 h / Heating View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 346, # 2-3 p. 185 - 189
反应条件
1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 2: 82 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 8 p. 2169 - 2186
反应条件
1: 41 percent / Et3N / CH2Cl2 / 2 h / 23 °C 2: (-)-sparteine; O2; Molecular sieves 3A / Pd(nbd)Cl2 / toluene / 24 h / 80 °C / 760.05 Torr 3: 78 percent / LiAlH4 / tetrahydrofuran / 5.5 h / Heating View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 346, # 2-3 p. 185 - 189
反应条件
1: 100 percent / NaBH4 / ethanol / 3 h / 0 - 23 °C 2: (-)-sparteine; O2; Molecular sieves 3A / Pd(nbd)Cl2 / toluene / 24 h / 80 °C / 760.05 Torr 3: 78 percent / LiAlH4 / tetrahydrofuran / 5.5 h / Heating View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 346, # 2-3 p. 185 - 189
反应条件
1: (-)-sparteine; O2; Molecular sieves 3A / Pd(nbd)Cl2 / toluene / 24 h / 80 °C / 760.05 Torr 2: 78 percent / LiAlH4 / tetrahydrofuran / 5.5 h / Heating View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 346, # 2-3 p. 185 - 189
反应条件
1: 70 percent / tetrahydrofuran; H2O / 70 °C 2: 90 percent / LiAlH4 / tetrahydrofuran / 0 - 25 °C View Scheme
参考文献
Synlett, , # 15 p. 2395 - 2398
反应条件
1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C 2: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C 3: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 4: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 5: 82 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 8 p. 2169 - 2186
反应条件
1.1: 95 percent / Et3N / CH2Cl2 / 0 h / -10 °C 2.1: O2; (-)-sparteine; 3 Angstroem sieves / Pd(OAc)2 / toluene / 36 h / 80 °C / 760 Torr 2.2: H2O / tetrahydrofuran / 65 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 31 p. 5435 - 5436
反应条件
1: 100 percent / NaI / acetone / Heating 2: 85 percent / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 7 p. 1412 - 1417
