(S)-3-(甲基氨基)-1-苯丙醇合成路线 （共 40 条）
反应条件
1: sodium bis(2-methoxyethoxy)aluminum hydride (Red-Al) / 1,2-dimethoxy-ethane; toluene / 3 h / Ambient temperature 2: 85 percent / triethylamine / diethyl ether / 3 h / -10 - 0 °C 3: 96 percent / H2O; tetrahydrofuran / 3 h / 65 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 17 p. 4081 - 4084
反应条件
1: 64 percent / H2O / 48 h / 27 °C / Geotrichium candidum 2: 80 percent / LiAlH4 / diethyl ether / Ambient temperature 3: 85 percent / Et3N / diethyl ether / 2 h / 0 °C 4: 90 percent / NaI / acetone / Heating 5: 86 percent / tetrahydrofuran; H2O / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 48, # 33 p. 6769 - 6776
反应条件
1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C 2: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 3: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 4: 82 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 8 p. 2169 - 2186
反应条件
1: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 2: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 3: 82 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 8 p. 2169 - 2186
反应条件
1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C 1.2: tetrahydrofuran; hexane / 1 h / -78 °C 2.1: DCC; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C 3.1: Candida rugosa lipase; MgCl2 / H2O; diisopropyl ether / 24 h / 30 °C 4.1: 95 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C 5.1: 85 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C / cooling 6.1: 82 percent / tetrahydrofuran; H2O / 4 h / 60 - 65 °C View Scheme
参考文献
Tetrahedron, , vol. 61, # 8 p. 2169 - 2186
反应条件
1: LiAlH4 / diethyl ether 2: pyridine / CH2Cl2 4: 100 percent / K2CO3, MeOH 5: NaI / H2O View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 3, # 4 p. 525 - 528
反应条件
1: pyridine / CH2Cl2 3: 100 percent / K2CO3, MeOH 4: NaI / H2O View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 3, # 4 p. 525 - 528
反应条件
2: 100 percent / K2CO3, MeOH 3: NaI / H2O View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 3, # 4 p. 525 - 528
反应条件
1: 100 percent / K2CO3, MeOH 2: NaI / H2O View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 3, # 4 p. 525 - 528
反应条件
sodium iodide in water
参考文献
Tetrahedron Asymmetry, , vol. 3, # 4 p. 525 - 528
