C3H6C9H10N4 in N,N-dimethyl-formamide T=20°C; 18 h; Inert atmosphere;

Multi-step reaction with 2 steps 1.1: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere2.2: 25 h / 0 - 90 °C / Inert atmosphere