3,4-二氟-2-甲基苯胺合成路线 （共 6 条）
反应条件
nickel in ethanol 1 h; Heating;
参考文献
Miyamoto; Ueda; Otsuka; Aki; Tamaoka; Tominaga; Nakagawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2472 - 2475
反应条件
hydrogenchloride in diethyl ether 0.666667 h; Ambient temperature;
参考文献
Carretero; Garcia Ruano; Vicioso
Tetrahedron, 1992 , vol. 48, # 35 p. 7373 - 7382
反应条件
1.1: triethylamine / toluene / 20 °C 2.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -60 - -55 °C / |Molecular sieve; |Inert atmosphere 2.2: 3 h / -40 - 20 °C / |Molecular sieve; |Inert atmosphere 3.1: hydrogenchloride; sodium hydroxide / ethanol; diethyl ether / 24 h / |Molecular sieve; |Inert atmosphere View Scheme
参考文献
Yoshida, Yasuo; Hamada, Yusuke; Umezu, Kazuto; Tabuchi, Fumiya
Organic Process Research and Development, 2004 , vol. 8, # 6 p. 958 - 961
反应条件
1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -60 - -55 °C / |Molecular sieve; |Inert atmosphere 1.2: 3 h / -40 - 20 °C / |Molecular sieve; |Inert atmosphere 2.1: hydrogenchloride; sodium hydroxide / ethanol; diethyl ether / 24 h / |Molecular sieve; |Inert atmosphere View Scheme
参考文献
Yoshida, Yasuo; Hamada, Yusuke; Umezu, Kazuto; Tabuchi, Fumiya
Organic Process Research and Development, 2004 , vol. 8, # 6 p. 958 - 961
反应条件
1: 54 percent / N-chlorosuccinimide, NEt3 / CH2Cl2 / 1) -15 deg C, 2) reflux, 14 h 2: 80 percent / Raney Ni / ethanol / 1 h / Heating View Scheme
参考文献
Miyamoto; Ueda; Otsuka; Aki; Tamaoka; Tominaga; Nakagawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2472 - 2475
反应条件
1: 75 percent / 1.5 h / 110 °C / Heating 2: 60 percent / diphenyl ether / 6 h / 220 °C 3: 90 percent / 2M NaOH / ethanol / 6.5 h / Heating View Scheme
参考文献
Carretero; Garcia Ruano; Vicioso
Tetrahedron, 1992 , vol. 48, # 35 p. 7373 - 7382
