反应条件
Multi-step reaction with 14 steps 1: pyridine / 24 h / Ambient temperature2: potassium acetate / 3 h / Heating3: ozone / CH2Cl2 / 0.08 h / -70 °C4: 87 percent / toluene / 15 h / Heating5: 100 percent / H2 / Pd-C (10percent) / ethyl acetate / 2 h6: 1.) LDA; / 1.) THF-10percent HMPA, -70 deg C, 30 min; 2.) -70 deg C, 10 min7: 88 percent / LiAlH4 / diethyl ether / 0.5 h / Ambient temperature8: 92 percent / PCC / CH2Cl2 / 1 h9: 94 percent / tetrahydrofuran / 1 h / 0 °C10: 95 percent / m-chloroperbenzoic acid / CH2Cl2 / 7 h / Ambient temperature11: 1.) lithium diphenylphosphide; 2.) MeI / 1.) THF, room temp., 10 h; 2.) room temp., 30 min12: benzyltriethylammonium chloride (BTEAC), NaOH (50percent) / H2O / 36 h / Ambient temperature13: Li / liquid ammonia; diethyl ether / 5 h / -70 °C14: toluene-p-sulphonic acid / dioxane; H2O / 1 h / Heating
参考文献
Cho, Jin-Ho; Djerassi, Carl Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1307 - 1318