N-苄氧羰基-L-丙氨酸合成路线 （共 167 条）
反应条件
1: N-carbobenzoxy-L-alanine With 1,2,2-trichloro-1,1,2-trichloro-ethane; triphenylphosphine in tetrahydrofuran T=0°C; 1.5 h; 2: (2S-trans)-L-glutamine With potassium hydroxide in tetrahydrofuran; dichloromethane; water T=0°C; pH=13; 2 h; 3: With sulfuric acid; hydrogen Product distribution / selectivity; more than 3 stages;
参考文献
Zhao, Yufen; Tang, Guo; Zhou, Ning; Hu, Liming; Chen, Yong
Patent: US2005/233977 A1, 2005 ;
Location in patent: Page/Page column 4-5 ;
反应条件
dicyclohexyl-carbodiimide in 1,4-dioxane; dichloromethane T=0°C;
参考文献
Szczepanska; Tarnowski; Jurczak
Polish Journal of Chemistry, 2005 , vol. 79, # 12 p. 1909 - 1917
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; 0.5 h;
参考文献
Bailen, Miguel A; Chinchilla, Rafael; Dodsworth, David J; Najera, Carmen
Tetrahedron Letters, 2002 , vol. 43, # 9 p. 1661 - 1664
反应条件
pyridine in acetonitrile T=20°C; 1.5 h; further solvent, base;
参考文献
Il'ina, A. V.; Davidovich, Yu. A.; Rogozhin, S. V.; Moiseenkov, A. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, p. 1067 - 1070
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 5 p. 1163 - 1165
反应条件
4-methyl-morpholine in tetrahydrofuran; acetonitrile Ambient temperature;
参考文献
Jaoudai, Mahmoud; Martinez, Jean; Castro, Bertrand
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2364 - 2367
参考文献
Ogura, Haruo; Nagai, Sachiko; Takeda, Kazuyoshi
Tetrahedron Letters, 1980 , vol. 21, p. 1467 - 1468
反应条件
pyridine in acetonitrile 5 h;
参考文献
Takeda, Kazuyoshi; Sawada, Izumi; Suzuki, Akira; Ogura, Haruo
Tetrahedron Letters, 1983 , vol. 24, # 41 p. 4451 - 4454
反应条件
pyridine in acetonitrile
参考文献
Griffin, Martin; Mongeot, Alexandre; Collighan, Russell; Saint, Robert E.; Jones, Richard A.; Coutts, Ian G.C.; Rathbone, Daniel L.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5559 - 5562
参考文献
Milne,H.B.; Most,C.F.
Journal of Organic Chemistry, 1968 , vol. 33, # 1 p. 169 - 175
反应条件
(i) Et3N, ClCO2Et, THF, (ii) /BRN= 1723527/, aq. NaOH; Multistep reaction;
参考文献
Shiba,T. et al.
Bulletin of the Chemical Society of Japan, 1968 , vol. 41, p. 2748 - 2753
