N-苄氧羰基-L-丙氨酸合成路线 （共 167 条）
反应条件
2: 47 percent / Et3N / tetrahydrofuran; H2O / 7 h / Ambient temperature View Scheme
参考文献
Kouge; Koizumi; Okai; Kato
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 7 p. 2409 - 2418
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0°C; Inert atmosphere;
参考文献
Vishwanatha; Narendra; Chattopadhyay, Basab; Mukherjee, Monika; Sureshbabu, Vommina V.
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2689 - 2702
反应条件
2: 47 percent / Et3N / tetrahydrofuran; H2O / 7 h / Ambient temperature View Scheme
参考文献
Kouge; Koizumi; Okai; Kato
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 7 p. 2409 - 2418
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=0°C; Inert atmosphere;
参考文献
Vishwanatha; Narendra; Chattopadhyay, Basab; Mukherjee, Monika; Sureshbabu, Vommina V.
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2689 - 2702
反应条件
TEA; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one in tetrahydrofuran T=20°C; 2 h;
参考文献
Li; Jiang; Ye; Fan; Romoff; Goodman
Organic letters, 1999 , vol. 1, # 1 p. 91 - 93
反应条件
bislt;lt;4-(2,2-dimethyl-1,3-dioxolyl)methylgt;carbodiimide; triethylamine in N,N-dimethyl-formamide 24 h; Ambient temperature;
参考文献
Gibson, Frank S.; Park, Myung Sook; Rapoport, Henry
Journal of Organic Chemistry, 1994 , vol. 59, # 24 p. 7503 - 7507
反应条件
1: 85 percent Spectr. / 4-dimethylaminopyridine; triethylamine; BOC2O / CH2Cl2 / 2.5 h / 20 °C 2: 95 percent / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Cabaret, Daniel; Wakselman, Michel
Tetrahedron Letters, 1994 , vol. 35, # 51 p. 9561 - 9564
反应条件
sodium hydrogencarbonate; 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride in water T=0°C; 2 h; optical yield given as percent de;
参考文献
Zajac, Krzysztof; Kaminski, Zbigniew J.
Acta Poloniae Pharmaceutica - Drug Research, 2010 , vol. 67, # 6 p. 725 - 728
反应条件
1: 88 percent / ethyl 1,2-dihydro-2-ethoxyquinoline-1-carboxylate / CH2Cl2 / 24 h / Ambient temperature 2: 100 percent Spectr. / ammonium hydrogen carbonate, H2O / CH2Cl2 / 24 h / α-chymotrypsin View Scheme
参考文献
Verardo; Gorassini
Journal of Peptide Science, 2013 , vol. 19, # 5 p. 315 - 324
反应条件
4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran T=20°C;
参考文献
Deska, Jan; Kazmaier, Uli
Chemistry - A European Journal, 2007 , vol. 13, # 21 p. 6204 - 6211
