N-苄氧羰基-L-丙氨酸合成路线 （共 167 条）
反应条件
thionyl chloride; zinc(II) chloride in tetrahydrofuran; hexane; water
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US6043376 A1, 2000 ;
反应条件
N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in N,N-dimethyl-formamide
参考文献
Kiso,Y.; Yajima,H.
Journal of the Chemical Society, Chemical Communications, 1972 , p. 942 - 943
反应条件
(i) 1-(4-chloro-phenyl)-3-(4-methyl-piperazin-1-yl)-prop-2-yn-1-one, CH2Cl2, (ii) /BRN= 3917353/, 4-methyl-morpholine; Multistep reaction;
参考文献
Neuenschwander,M. et al.
Helvetica Chimica Acta, 1978 , vol. 61, p. 2437 - 2451
反应条件
1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in ethyl acetate T=20°C; 16 h;
参考文献
Nuijens, Timo; Cusan, Claudia; Kruijtzer, John A. W.; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; Quaedflieg, Peter J. L. M.
Journal of Organic Chemistry, 2009 , vol. 74, # 15 p. 5145 - 5150
反应条件
potassium carbonate in N,N-dimethyl-formamide T=0 - 20°C; 1.5 h;
参考文献
Bayer, Annette; Endeshaw, Molla Mellese; Gautun, Odd R.
Journal of Organic Chemistry, 2004 , vol. 69, # 21 p. 7198 - 7205
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide 4 h; Ambient temperature;
参考文献
Wyslouch, Aleksandra; Lisowski, Marek; Pedyczak, Artur; Siemion, Ignacy Z.
Tetrahedron: Asymmetry, 1992 , vol. 3, # 11 p. 1401 - 1410
反应条件
in N,N-dimethyl-formamide 16 h; Ambient temperature;
参考文献
Gibson, Frank S.; Park, Myung Sook; Rapoport, Henry
Journal of Organic Chemistry, 1994 , vol. 59, # 24 p. 7503 - 7507
参考文献
Huneck, S.; Porzel A.
Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1994 , vol. 49, # 4 p. 569 - 575
反应条件
in methanol; hexane Ambient temperature;
参考文献
Marcovici-Mizrahi, Dana; Gottlieb, Hugo E.; Marks, Vered; Nudelman, Abraham
Journal of Organic Chemistry, 1996 , vol. 61, # 24 p. 8402 - 8406
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine 1.) CH2Cl2, 0 deg C, 10 min, 2.) 0 deg C, 15 min; Yield given. Multistep reaction;
参考文献
Kim, Sunggak; Lee, Jae In; Kim, Youn Chul
Journal of Organic Chemistry, 1985 , vol. 50, # 5 p. 560 - 565
