N-苄氧羰基-L-丙氨酸合成路线 （共 167 条）
反应条件
sodium hydride in tetrahydrofuran 24 h; Ambient temperature;
参考文献
Blackburn, G. Michael; Lilley, Terence H.; Milburn, Peter J.
Journal of Solution Chemistry, 1986 , vol. 15, # 2 p. 99 - 108
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4470973 A1, 1984 ;
US 4470973 A
反应条件
n-ethyl morpholine; hexamethylphosphorous triamide dichloride in dichloromethane 1) 0 deg C, 2 h, 2) overnight, r.t.;
参考文献
Appel, Rolf; Glaesel, Ursula
Chemische Berichte, 1980 , vol. 113, # 11 p. 3511 - 3516
参考文献
Goodman; Stueben
Journal of the American Chemical Society, 1959 , vol. 81, p. 3980,3982
反应条件
chloroform; chloroformic acid ethyl ester; triethylamine
anschliessend Behandeln mit L-Serin-methylester in CHCl3;
参考文献
Saha, Ashis K.; Schultz, Peter; Rapoport, Henry
Journal of the American Chemical Society, 1989 , vol. 111, # 13 p. 4856 - 4859
反应条件
triethylamine; dicyclohexyl-carbodiimide in chloroform
参考文献
Kricheldorf, Hans R.
Organic Magnetic Resonance, 1981 , vol. 15, # 2 p. 162 - 177
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride
Inert atmosphere;
参考文献
Kita, Yusuke; Nishii, Yuji; Higuchi, Takafumi; Mashima, Kazushi
Angewandte Chemie - International Edition, 2012 , vol. 51, # 23 p. 5723 - 5726
反应条件
boron trifluoride diethyl etherate in diethyl ether
T=-15°C; 96 h;
参考文献
Long, Ya-Qiu; Xue, Ting; Song, Yan-Li; Liu, Zu-Long; Huang, Shao-Xu; Yu, Qiang
Journal of Medicinal Chemistry, 2008 , vol. 51, # 20 p. 6371 - 6380
反应条件
pyridine; sodium chloride; triethylamine in N,N-dimethyl-formamide
参考文献
Ogura; Haruo
Patent: US4341707 A1, 1982 ;
反应条件
1.1: SOCl2 / tetrahydrofuran / 0.33 h / 25 °C
1.2: 95 percent / tetrahydrofuran / 1 h / 25 °C
2.1: 90 percent / Et3N / acetonitrile; H2O / 20 °C
View Scheme
参考文献
Gibson, Frank S.; Park, Myung Sook; Rapoport, Henry
Journal of Organic Chemistry, 1994 , vol. 59, # 24 p. 7503 - 7507
