N-苄氧羰基-L-丙氨酸合成路线 （共 167 条）
反应条件
(i) 1-(4-chloro-phenyl)-3-(4-methyl-piperazin-1-yl)-prop-2-yn-1-one, CH2Cl2, (ii) /BRN= 3913214/, 4-methyl-morpholine; Multistep reaction;
参考文献
Neuenschwander,M. et al.
Helvetica Chimica Acta, 1978 , vol. 61, p. 2437 - 2451
反应条件
4-methyl-morpholine; dicyclohexyl-carbodiimide in ethyl acetate
T=-5°C; 2.5 h;
参考文献
Khabarova, E. I.; Zvonkova, E. N.; Evstigneeva, R. P.; Chupin, V. V.; Kulish, M. A.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 4 p. 938 - 945,836 - 841
反应条件
p-toluenesulfonic acid monohydrate; paraformaldehyde in toluene
参考文献
Mitsui Chemicals, Inc.
Patent: EP1340743 A1, 2003 ;
反应条件
toluene-4-sulfonic acid in benzene
1 h; Heating;
参考文献
Walter, Magnus W.; Adlington, Robert M.; Baldwin, Jack E.; Schofield, Christopher J.
Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 5179 - 5192
反应条件
toluene-4-sulfonic acid in toluene
4 h; Ambient temperature;
参考文献
Dorow; Gingrich, Diane E.
Tetrahedron Letters, 1999 , vol. 40, # 3 p. 467 - 470
反应条件
1,4-dioxane; tributyl-amine; chloroformic acid ethyl ester
anschliessendes Behandeln mit L-Glutaminsaeure-dibenzylester-hydrochlorid und Tributylamin in Dioxan;
参考文献
Sachs; Brand
Journal of the American Chemical Society, 1953 , vol. 75, p. 4608
反应条件
dicyclohexyl-carbodiimide
参考文献
Ohyama, Satoshi; Ishibashi, Norio; Tamura, Masahiro; Nishizaki, Hiroshi; Okai, Hideo
Agricultural and Biological Chemistry, 1988 , vol. 52, # 3 p. 871 - 872
